I do not know what field RMS is in. However, in most areas of biology in the US of which I am aware, you won’t even get considered for an interview for a tenure-track assistant professor job at a RO1 research university if you don’t have a first author publication in Nature, Science or Cell. This has gone beyond publish-or-perish, for reasons that Pesante notes below.
Unfortunately, if an Academic career is what you want out of life, these are the ground rules.
Comment on University of Pristina Rector under Fire for Publishing in Predatory Journals by Jill M
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