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Comment on Scholarly Authors are Increasingly Experiencing APC Fatigue by Benno v. Bormann

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Harvey, thank’s for the discussion. I recommend a research on Fibrinogen concentrate (FBC). It’s a promising agent, but scientific evidence is still lacking except for few specific indications. Check the conclusions of the respective researchers and correlate it with the conflicts of interest. All groups, and I mean ALL promoting the generous use of FBC in various clinical settings being published in highest ranking organs are on the payroll of Behring (FBC), the No 1 producer of FBC. I’m talking about advisory board fees, publication and lecturing fees, travel expenses and so on. The few groups with carefull considerations, incl. Cochrane Review are entirely without conflicts o.I. To give an idea about the financial dimensions let’s consider only one country, and only one indication. In Germany with about 400,000 cardiosurgical procedures/year the prophylactic use of low-dose 2 g of fibrinogen concentrate per cardiosurgical patient as promoted by some would be equivalent to a sales volume of approx 300,000,000 Euro/year. Sorry, I don’t share your optimism. Open access with total transparency of the review process may be a step in the right direction.


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